Been watching Darkwing Duck lately and noticed quite a few similarities between Reginald Bushroot and Star Trek's Reginald Barclay. The name for one, they're both rather shy and introverted.
They both are in dire need of friends and instead of going out and finding them they choose to try and create their own, Barclay through the Holodeck and Bushroot through his plant experiments.
Both have had major physical changes happen to them: Bushroot turned into a plant and Barclay has been turned into a spider-thing, had his IQ boosted into the thousands and been altered by the transporter. (although none of his problems were permanent)